Imatinib is still recommended for frontline therapy for CML
نویسندگان
چکیده
منابع مشابه
Is imatinib still an acceptable first-line treatment for CML in chronic phase?
The introduction of the tyrosine kinase inhibitor (TKI) imatinib (Gleevec) into clinical practice resulted in a very dramatic prolongation of survival for most, but not all, patients with chronic myeloid leukemia in chronic phase (CML-CP). A leukemia with a median survival of about 5 years was transformed into one for which the survival in many cases promises to be comparable to that of normal ...
متن کاملLong-term imatinib therapy promotes bone formation in CML patients.
Imatinib inhibits tyrosine kinases important in osteoclast (c-Fms) and osteoblast (platelet-derived growth factor receptor [PDGF-R], c-Abl) function, suggesting that long-term therapy may alter bone homeostasis. To investigate this question, we measured the trabecular bone volume (TBV) in iliac crest bone biopsies taken from chronic myeloid leukemia (CML) patients at diagnosis and again after 2...
متن کاملis vancomycine still a choice for chronic osteomyelitis empirical therapy in iran?
background pyogenic bacteria and especially staphylococcus aurous (s. aurous) are the most common cause of chronic osteomyelitis. not only treatment protocol of chronic osteomyelitis occasionally is amiss but also this malady responds to treatment difficultly. objectives this study investigates antibiotic resistance pattern of s. aurous isolated from iranian patients who suffer from chronic ost...
متن کاملManagement of imatinib-resistant CML patients.
Imatinib has had marked impact on outcomes in chronic myelogenous leukemia (CML) patients for all stages of the disease and is endorsed by international treatment guidelines as the first line option. Although imatinib is highly effective and well tolerated, the development of resistance represents a clinical challenge. Since the most frequently identified mechanism of acquired imatinib resistan...
متن کاملIs Trans Fatty Acid Still an Issue for Policy Makers in Iran? A Technical Report
In recent decades, the oil industry has changed its direction toward vegetable oil use instead of animal fats due to various reasons such as a small numbers of animal fat resources and high saturated fatty acids content in animal fats. Therefore, different modification processes have been used to alter the physicochemical properties of vegetable oils, which lack functionality and oxidative stab...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Blood Advances
سال: 2018
ISSN: 2473-9529,2473-9537
DOI: 10.1182/bloodadvances.2018018614